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Lonidamine

CAS No. : 50264-69-2

MCE 国际站：Lonidamine

产品活性：Lonidamine (AF-1890) 是一种己糖激酶 (hexokinase) 和丙酮酸载体 (mitochondrial pyruvate carrier) 抑制剂 (K_i: 2.5 μM)。Lonidamine 还可抑制癌细胞中的有氧糖酵解。Lonidamine 可用于线粒体代谢和炎症的研究，如肺纤维化。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis  |  Anti-infection

作用靶点：Hexokinase  |  Mitochondrial Metabolism  |  Apoptosis  |  Parasite

In Vitro: Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.
Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.
Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.
Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.
Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.

In Vivo: Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.

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