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Nabumetone

CAS No. : 42924-53-8

MCE 国际站：Nabumetone

产品活性：Nabumetone 是一种可口服的非酸类抗炎剂，为有效的、选择性的 COX-2 抑制剂，同时是活性代谢物 6MNA 的前体物质。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vitro: Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression.

In Vivo: Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE₂ in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF_1α production in rats. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats.

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