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CAS No. : 105956-97-6
MCE 国际站:Clinafloxacin
产品活性:Clinafloxacin (AM 1091) 是一种高效广谱氟喹诺酮类抗生素 (antibiotic),对革兰氏阳性、革兰氏阴性和厌氧病原体均有抑制活性。Clinafloxacin 对金黄色葡萄球菌的 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 有抑制作用,IC50 值分别为 0.92 µg/ml 和 1.62 µg/ml。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants.Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus. It against Wild type S. aureus, gyrA mutant S. aureus and gyrA mutant S. aureus with MIC values of 0.016 µg/ml, 0.063 µg/ml and 0.915 µg/ml, respectively.
In Vivo: Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.
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