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Pentagamavunon-1

CAS No. : 27060-70-4

MCE 国际站：Pentagamavunon-1

产品活性：Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。

研究领域：Apoptosis  |  Immunology/Inflammation  |  Protein Tyrosine Kinase/RTK  |  NF-κB

作用靶点：Apoptosis  |  COX  |  VEGFR  |  NF-κB

In Vitro: Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells.
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest.

In Vivo: Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity.

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