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6-Azathymine

CAS No. : 932-53-6

MCE 国际站：6-Azathymine

产品活性：6-Azathymine，胸腺嘧啶的 6-氮类似物，是一种有效的 D-3-氨基异丁酸酯-丙酮酸氨基转移酶 (D-3-aminoisobutyrate-pyruvate aminotransferase) 抑制剂。6-Azathymine 可抑制 DNA 的生物合成，并具有抗菌和抗病毒活性。

研究领域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：Nucleoside Antimetabolite/Analog  |  DNA/RNA Synthesis  |  Bacterial  |  Influenza Virus

In Vitro: 6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine.

In Vivo: The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-¹⁴C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives.

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