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ASN007

CAS No. : 2055597-12-9

MCE 国际站：ASN007

产品活性：ASN007 (ERK-IN-3) 是一种有效和具有口服活性的 ERK 抑制剂。 ASN007 以较低的 IC₅₀ 值抑制 ERK1/2。 ASN007 可用于研究由 RAS 突变驱动的癌症。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt

作用靶点：ERK

In Vitro: ASN007 (ERK-IN-3) inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines.
ASN007 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines.

In Vivo: ASN007 (ERK-IN-3) (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses.

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