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Z-FA-FMK

CAS No. : 197855-65-5

MCE 国际站：Z-FA-FMK

产品活性：Z-FA-FMK ((1S)-Z-FA-FMK) 是一种有效的组织蛋白酶 B 和 L 抑制剂。Z-FA-FMK 通过选择性合成类维生素 a 相关分子 (RRMs) 阻断 DEVDase 活性、DNA 片段化和磷脂酰丝氨酸外化的诱导。Z-FA-FMK 抑制细胞凋亡 (apoptosis)。Z-FA-FMK 可抑制 caspase 活性，并选择性抑制重组效应蛋白 caspase 2、-3、-6 和 -7。Z-FA-FMK 是一种病毒抑制剂。Z-FA-FMK 抑制呼肠孤病毒在易感宿主中的复制。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：SARS-CoV  |  Cathepsin  |  Apoptosis  |  Caspase

In Vitro: Z-FA-FMK ((1S)-Z-FA-FMK; 5-100 μM; 1 h; Jurkat cells) reduces levels of DEVDase activity and DNA fragmentation. Z-FA-FMK inhibits the externalization of phosphatidylserine induced by either MX2870-1 or MX781.
Z-FA-FMK (100 μM; 1 h; Jurkat cells) inhibits apoptosis. Z-FA-FMK inhibited the induction of DEVDase activity not only by the RRMs but also by other apoptotic insults, including etoposide-, ceramide-, and CD95/Fas receptor-mediated pathways.
Z-FA-FMK (0-100 μM; 1 h; Jurkat cells) inhibits caspases 2, -3, -6, and -7 activity through repressed induction of DEVDase activity in Jurkat cells.
Z-FA-FMK (0-20 μM; 48 h; HT1080 and mouse embryonic stem cells) blocks reoviral replication and cures cells of a persistent infection with reovirus in vitro.
Z-FA-FMK (20 μM; 48 h; HT1080 cells) induces defects in reoviral maturation.

In Vivo: Z-FA-FMK (1 mg/kg; intratumor injection; every 2 d, for 27 d; SCID mice with HT1080 xenograft) blocks reovirus infection in vivo.
Z-FA-FMK (8 mg/kg; i.v.; every 2 d, once; male BALB/c mice) markedly lessens the degree of impairment seen in D-GalN/TNF-α-induced kidney injury.

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