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CAS No. : 1637573-04-6
MCE 国际站:Ralaniten triacetate
产品活性:Ralaniten triacetate (EPI-506) 是 Ralaniten 的前体,是一种首创的,具有口服活性的雄激素受体 (AR) N 端结构域 (NTD) 抑制剂。Ralaniten triacetate 对全长和与抗性相关的 AR 物种,包括 AR-v7 都有活性。
研究领域:Vitamin D Related/Nuclear Receptor
作用靶点:Androgen Receptor
In Vitro: Ralaniten triacetate (EPI-506) targets the N-terminal domain of the androgen receptor (AR), and is used for metastatic castration-resistant prostate cancer (mCRPC) research. EPI-506 is a first-in-class, highly-specific small molecule that binds to a novel target on the AR, the N-terminal domain (NTD) and directly inhibits AR transcriptional activity by blocking the interaction of the AR with transcriptional proteins.
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