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CAS No. : 3963-95-9
MCE 国际站:Methacycline hydrochloride
产品活性:Methacycline hydrochloride 是一种四环素抗生素,可以抑制细菌蛋白质的合成。Methacycline hydrochloride 是一种有效的上皮-间质转化 (EMT) 抑制剂。Methacycline hydrochloride 在体外可阻断 EMT,体内抑制纤维发生,不会直接影响 TGF-β1 Smad 信号传导。Methacycline hydrochloride 是一种抗菌剂,具有用于肺纤维化研究的潜力。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Methacycline hydrochloride is an inhibitor of A549 EMT with an IC50 of roughly 5 μM.
In vitro, Methacycline hydrochloride (10, 20 μM; for 48 hours) inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline hydrochloride inhibits TGF-β1–induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1.
In Vivo: In vivo, Methacycline hydrochloride (100 mg/kg/day; ip; beginning 10 days after intratracheal Bleomycin) improves survival at Day 17. Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA, ARE attenuated by Methacycline hydrochloride (Day 17).
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