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Amantadine hydrochloride

CAS No. : 665-66-7

MCE 国际站：Amantadine hydrochloride

产品活性：Amantadine (1-Adamantanamine) hydrochloride 是一种口服有效的抗甲型流感 (influenza A) 病毒的抗病毒剂。Amantadine hydrochloride 对 NMDA、M2 等多种离子通道均有抑制作用。Amantadine hydrochloride 还具有抗正痘病毒 (orthopoxvirus) 和抗癌 活性。Amantadine hydrochloride 可用于帕金森病，术后认知功能障碍 (POCD) 和 COVID-19 的研究。

研究领域：Anti-infection  |  Apoptosis  |  Cell Cycle/DNA Damage

作用靶点：Influenza Virus  |  Orthopoxvirus  |  SARS-CoV  |  Apoptosis  |  Bcl-2 Family  |  CDK

In Vitro: Amantadine hydrochloride (0-500 µM, 26 h) inhibits SARS-CoV-2 replication, with IC₅₀ concentrations between 83 and 119 µM.
Amantadine hydrochloride (0-100 µg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC‑7721 cells.
Amantadine hydrochloride (0-75 µg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis.
Amantadine hydrochloride (0-75 µg/mL, 48 h) reduces the levels of the cell cycle‑related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels.

In Vivo: Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment.

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