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Phenoxybenzamine hydrochloride

CAS No. : 63-92-3

MCE 国际站：Phenoxybenzamine hydrochloride

产品活性：Phenoxybenzamine hydrochloride 是一种非选择性的、不可逆的、具有口服活性的 α-肾上腺素受体（α-adrenoceptor）拮抗剂，常用于研究嗜铬细胞瘤引起的高血压。 Phenoxybenzamine hydrochloride 也具有抗肿瘤活性。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Phenoxybenzamine hydrochloride (0-100 μM; 96 h) markedly inhibits U251 and U87MG cells proliferation.
Phenoxybenzamine hydrochloride (10 μM; 24 h or 72 h) inhibits migration and invasion of U251 and U87MG cells.
Phenoxybenzamine hydrochloride (10 μM; 12 h) activates LINGO-1 and inhibits the TrkB-Akt pathway.
Phenoxybenzamine (0.1 μM-1 mM; 0-16 h) prevents hippocampal cell death after oxygen glucose deprivation.

In Vivo: Phenoxybenzamine hydrochloride (20 nM; s.c.; 2-day interval for 26 days) shows anti-tumorigenic effect in mice.
Phenoxybenzamine (1.0 mg/kg; i.v.; daily for 30 days) is neuroprotective in a rat model of severe traumatic brain injury.

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