MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 150651-39-1
MCE 国际站:iFSP1
产品活性:iFSP1 是 FSP1 (AIFM2) 的选择性有效抑制剂,EC50 值为 103 nM。iFSP1 可选择性地诱导过表达 FSP1 的 GPX4 敲除细胞发生铁死亡 (ferroptosis)。iFSP1 可增强多种人癌细胞系对铁死亡诱导剂的敏感度,如: (1S,3R)-RSL3 (HY-100218A)。
研究领域:Apoptosis
作用靶点:Ferroptosis
In Vitro: iFSP1 (0.001-1 μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.iFSP1 (0.001-1 μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.iFSP1 (3 μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1)
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Ferroptosis Compound Library | Targeted Diversity Library | Cuproptosis Compound Library | Heterocyclic Compound Library | Highly Selective Activators Library | Sorafenib-d4 | Lapatinib ditosylate | Ciclopirox olamine | Curcumin | L-Glutamine-d5 | HDAC-IN-48 | (S)-L-Cystine-15N2 | L-Glutamine-13C5,15N2 | Lapatinib-d7 dihydrochloride | Sorafenib Tosylate | Deferiprone | Cycloheximide | Pravastatin sodium | YL-939 | (-)-Epicatechin | Dopamine-d5 hydrochloride | Linagliptin-d4 | Acetylcysteine-d3 | Dopamine hydrochloride | (E)-Ferulic acid | PD146176 | Pifithrin-β hydrobromide | Pseudolaric Acid B | L-Glutamic acid-d5 | Roxadustat | Matrine | Liproxstatin-1 | L-Glutamic acid-13C5,15N,d5 | Hemin
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。