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BIO-013077-01

CAS No. : 746667-48-1

MCE 国际站：BIO-013077-01

产品活性：BIO-013077-01 是一种吡唑类的 TGF-β 抑制剂。

研究领域：TGF-beta/Smad

作用靶点：TGF-β Receptor

In Vitro: A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies.

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