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CAS No. : 1447464-73-4
MCE 国际站:IHVR-19029
产品活性:IHVR-19029 是一种有效的内质网 α-葡萄糖苷酶 Ⅰ 和 Ⅱ (α-glucosidases I/II) 抑制剂,对 ER α-葡萄糖苷酶 Ⅰ 的 IC50 为 0.48 μM。IHVR-19029 能有效阻断几种出血热病毒的复制,如登革病毒、埃博拉病毒和裂谷热病毒。IHVR-19029 和 Favipiravir (HY-14768) 联合提高抗病毒活性。
研究领域:Metabolic Enzyme/Protease
作用靶点:Glucosidase
In Vitro: IHVR-19029 efficiently inhibits Bovine viral diarrhea virus (BVDV), Tacaribe virus (TCRV) and Dengue virus (DENV) with EC50s of 0.25, 0.74, and 1.25 μM, respectively.The combination of IHVR-19029 and Favipiravir (HY-14768) synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells.
In Vivo: IHVR-19029 (25-75 mg/kg; I.p.; twice daily for 10 days) inhibits EBOV and MARV infection in mice.
IHVR-19029 (5 mg/kg; i.v.) has AUC, C0, T1/2, CL and Vd values of 1383 μg*h/mL, 1.79 μg/mL, 1.2 hours, 3.49 L/h/kg, and 3.0 L/kg, respectively.
IHVR-19029 (75/5/5 mg/kg; p.o./i.m./i.p.) has AUC values of 945/1839/983 μg*h/mL, Cmax values of 0.26/1.23/1.33 μg/ml, Tmax values of 2.1/0.1/0.17 hours, and F values of 4.6/71/133%, respectively.
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