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PD-161570

CAS No. : 192705-80-9

MCE 国际站：PD-161570

产品活性：PD-161570 是一种有效的且具有 ATP 竞争能力的人 FGF-1 受体抑制剂，IC₅₀ 为 39.9 nM，K_i 为 42 nM。PD-161570 还抑制 PDGFR，EGFR 和 c-Src 酪氨酸激酶，IC₅₀ 值分别为 310 nM，240 nM 和 44 nM。PD-161570 抑制 PDGF 刺激的自磷酸化和 FGF-1 受体磷酸化，IC₅₀ 分别为 450 nM 和 622 nM。PD-161570 还是一种骨形态发生蛋白 (BMPs) 和 TGF-β 信号抑制剂。

研究领域：Protein Tyrosine Kinase/RTK  |  JAK/STAT Signaling  |  TGF-beta/Smad

作用靶点：FGFR  |  PDGFR  |  EGFR  |  Src  |  TGF-β Receptor

In Vitro: PD-161570 (Compound 6c; 0.1-1 µM; 1-8 days; VSMCs) treatment inhibits PDGF-stimulated vascular smooth muscle cell proliferation in a dose dependent fashion with an IC₅₀ of 0.3 µM on day 8.
PD-161570 suppresses constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A_121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A_121(p) cells in culture.
PD-161570 can potently inhibit basic fibroblast growth factor (bFGF)-mediated angiogenesis.

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