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CAS No. : 2414674-71-6
MCE 国际站:SUVN-911
产品活性:SUVN-911 是一种高效、选择性的,有大脑通透性和口服生物活性的神经元烟碱乙酰胆碱 α4β2 受体 (α4β2 receptor) 拮抗剂,Ki 值为 1.5 nM。SUVN-911 具有抗抑郁作用。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:nAChR
In Vitro: SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR.
SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins.
In Vivo: SUVN-911 is devoid of cardiovascular and gastrointestinal side effects.
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects.
SUVN-911 shows metabolic stability in rats.
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats.
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