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Topiramate

CAS No. : 97240-79-4

MCE 国际站：Topiramate

产品活性：Topiramate (McN 4853) 是一种广谱抗癫痫剂。Topiramate 也是一种 GluR5 受体拮抗剂，可通过增强 GABAergic 活性，抑制 kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：iGluR  |  GABA Receptor  |  Sodium Channel  |  Calcium Channel  |  Potassium Channel  |  Carbonic Anhydrase

In Vitro: Topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.

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