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Mizolastine

CAS No. : 108612-45-9

MCE 国际站：Mizolastine

产品活性：Mizolastine 是一种口服有效的，具有高亲和力和特异性的外周组胺 H1 受体拮抗剂 (第二代抗组胺剂)。Mizolastine 能有效抑制VEGF165、VEGF120、TNF-α 和 KC 的 mRNA 表达。Mizolastine 可用于过敏性鼻炎和慢性特发性荨麻疹的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Mizolastine (1-10000 nM; 0.5-6 h) shows inhibitory effects on VEGF, KC and TNF-α release in mast cells.
Mizolastine (0.1 µM; 4 h) significantly reduces VEGF165, VEGF120, TNF-α and KC mRNA expression in mast cells.

In Vivo: Mizolastine (0.3 mg/kg; p.o.; single daily for 7 days) inhibits production of 5-LOX AA (arachidonic acid) metabolite leukotriene B4 (LTB4), and suppresses expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model.

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