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CAS No. : 50-78-2
MCE 国际站:Aspirin
产品活性:Aspirin (Acetylsalicylic Acid) 是一种口服有效的不可逆的环氧合酶 COX-1 和 COX-2 抑制剂,IC50 分别为 5 和 210 μg/mL. Aspirin 诱导细胞凋亡 (apoptosis)。Aspirin 可抑制 NF-κB 的活化。Aspirin 还抑制血小板前列腺素合成酶 (prostaglandin synthetase),可预防冠状动脉和脑血管血栓形成。
研究领域:Immunology/Inflammation | Anti-infection | NF-κB | Autophagy | Apoptosis | MAPK/ERK Pathway
作用靶点:COX | Virus Protease | NF-κB | Autophagy | Apoptosis | Mitophagy | Caspase | p38 MAPK
In Vitro: Aspirin inhibits COX-1 and COX-2 in human articular chondrocytes, with IC50 values of 3.57 μM and 29.3 μM, respectively.
?Aspirin acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets and reducing platelet aggregation.
?Aspirin inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.
?Aspirin inhibits NF-κB-dependent transcription from the lgκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
?Aspirin induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, and activation of the ceramide pathway.
In Vivo: Aspirin can be used in animal modeling to construct gastrointestinal ulcer models.
Aspirin (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats.
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