MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 188062-50-2
MCE 国际站:Abacavir sulfate
产品活性:Abacavir sulfate (Abacavir Hemisulfate) 是一种竞争性的口服活性核苷逆转录酶(nucleoside reverse transcriptase)抑制剂。 Abacavir sulfate 可抑制 HIV 的复制。Abacavir sulfate 在前列腺癌细胞系中显示出抗癌活性。Abacavir sulfate 可突破血脑屏障,抑制端粒酶(telomerase)活性。
研究领域:Anti-infection | Cell Cycle/DNA Damage | Apoptosis
作用靶点:Reverse Transcriptase | HIV | Telomerase | Apoptosis
In Vitro: Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines.
Abacavir (15 and 150 μM, 18 h) sulfate significantly reduces cell migration and inhibits cell invasion.
Abacavir sulfate induces fat apoptosis.
In Vivo: Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) sulfate dose-dependently promoted thrombus formation.
Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice.
相关产品:Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | FDA-Approved Drug Library | Antiviral Compound Library | CNS-Penetrant Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Rare Diseases Drug Library | Children’s Drug Library | EMA-Approved Drug Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | SY-5609 | BRD4 Inhibitor-18 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | AAPK-25 | Peldesine dihydrochloride | Dutasteride-13C6 | Oleic acid-13C | Anticancer agent 120 | Meloxicam-d3-1 | Thailanstatin D | SB-218078 | Toyocamycin | HIV-IN-6 | Sorafenib-d4 | Busulfan | PTC-028 | Epicoccone B | Dinaciclib | CR-1-31-B | 142I5 | Farudodstat | Ecteinascidin 770 | AT9283 | Staurosporine | SNS-032 | AZA1 | Antitumor agent-96 | Bleomycin A5 | Ditiocarb
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。