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Rosuvastatin Calcium

CAS No. : 147098-20-2

MCE 国际站：Rosuvastatin Calcium

产品活性：Rosuvastatin Calcium 是一种竞争性 HMG-CoA 还原酶 (HMGCR) 抑制剂，IC₅₀ 为11 nM。Rosuvastatin Calcium 有效阻断 hERG 电流，IC₅₀ 为 195 nM。Rosuvastatin Calcium 降低成熟 hERG 的表达以及热休克蛋白 70 (Hsp70) 与 hERG 蛋白的相互作用。Rosuvastatin Calcium 有效降低低密度脂蛋白 (LDL) 胆固醇，甘油三酯和 C- 反应蛋白水平。

研究领域：Metabolic Enzyme/Protease  |  Autophagy  |  Membrane Transporter/Ion Channel  |  Anti-infection

作用靶点：HMG-CoA Reductase (HMGCR)  |  Autophagy  |  Potassium Channel  |  Bacterial

In Vivo: Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.

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