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CAS No. : 100986-85-4
MCE 国际站:Levofloxacin
产品活性:Levofloxacin ((-)-Ofloxacin) 是一种具有口服活性的抗生素,对革兰氏阳性和阴性细菌均有抑制效果。Levofloxacin 抑制 DNA 促旋酶(DNA gyrase)和拓扑异构酶 IV(topoisomerase IV)。Levofloxacin 可用于慢性牙周炎、气道炎症和 BK 病毒血症的研究。Levofloxacin 具有抗正痘活性。
研究领域:Cell Cycle/DNA Damage | Anti-infection
作用靶点:Topoisomerase | DNA/RNA Synthesis | Antibiotic | Bacterial | Orthopoxvirus
In Vitro: Levofloxacin shows inhibition effects to M. tuberculosis susceptible strains OFLO, LVFX, and SPFX with MIC50 values of 1.0, 0.5 and 0.25 μg/mL, respectively。
In Vivo: Levofloxacin (10.7 mg/kg; i.p., once daily for 10 days or 3 weeks) time-dependently induces toxic effects on liver and heart in albino mice.
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