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CAS No. : 1426944-49-1
MCE 国际站:HBX 19818
产品活性:HBX 19818 是一种泛素蛋白特异性蛋白酶 (USP7) 抑制剂,IC50 值为 28.1 μM。
研究领域:Cell Cycle/DNA Damage
作用靶点:Deubiquitinase
In Vitro: HBX 19818 is an inhibitor of USP7, with an IC50 of 28.1 μM. HBX 19818 shows no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3 or on SENP1, a SUMO protease, with IC50s of > 200 μM. HBX 19818 selectively inhibits USP7 with IC50 of ~6 μM in in human cancer cells. In addition, HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells. HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner, with an IC50 of ~2 μM.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Ubiquitination Compound Library | Highly Selective Inhibitors Library | SJB3-019A | USP8-IN-2 | SJB2-043 | USP7-IN-1 | USP7-IN-8 | DUB-IN-2 | HBX 41108 | USP7-IN-3 | P005091 | Thiolutin | b-AP15 | BAY-728 | 8RK64 | USP1-IN-3 | USP28-IN-2 | USP7-IN-6 | DC-U4106 | KSQ-4279 | 6-Thioguanine | GRL0617 | EOAI3402143 | GK13S | STAMBP-IN-1 | LDN-57444 | IU1-47 | USP15-IN-1 | USP25/28 inhibitor AZ1 | USP8-IN-1 | C527
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