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Lacidipine

CAS No. : 103890-78-4

MCE 国际站：Lacidipine

产品活性：Lacidipine 是一种口服有效的和具有高度选择性的 L 型钙离子通道阻滞剂，作用于平滑肌的钙通道，主要扩张周围动脉，减少外周阻力，具有长效抗高血压活性。Lacidipine 通过调节 caspase-3 途径来保护 HKCs 免受 ATP 耗尽和恢复所诱发的凋亡。Lacidipine 可用于高血压，动脉粥样硬化和急性肾脏损伤的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Calcium Channel  |  Reactive Oxygen Species  |  Caspase  |  Apoptosis

In Vitro: Lacidipine (0.01-100 μM; 24 h) inhibits HKCs proliferation in vitro in a concentration-dependent manner.
Lacidipine (0.01-100 μM; 24 h) protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway.

In Vivo: Lacidipine (0.3, 1.0, 3.0 mg/kg; p.o.; single daily for 10 weeks) shows anti-atherogenic effects in the apoE-deficient mouse, and reduces plasma endothelin concentrations.

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