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CAS No. : 54-85-3
MCE 国际站:Isoniazid
产品活性:Isoniazid (INH) 是一种前体,必须被细菌过氧化氢酶 KatG 激活。Isoniazid 对快速分裂的分枝杆菌具有杀菌作用,并具有抗菌活性。
研究领域:Anti-infection | Autophagy
作用靶点:Bacterial | Autophagy | Mitophagy | Antibiotic
In Vitro: Isoniazid (INH) is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG.
KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824.
Isoniazid is bactericidal to rapidly dividing mycobacteria but is bacteriostatic if the mycobacteria are slow-growing.
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