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Phentolamine mesylate

CAS No. : 65-28-1

MCE 国际站：Phentolamine mesylate

产品活性：Phentolamine mesylate (Phentolamine methanesulfonate) 是一种可逆的，非选择性和具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，可使血管扩张以减少周围血管阻力。Phentolamine mesylate 可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA₂ and pK_B of 7.92 and 8.07, respectively.
Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC₅₀s of 50 μg/mL and 30 μg/mL without toxicity, respectively.
Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) significantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.
Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.

In Vivo: Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.

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