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Bromhexine hydrochloride

CAS No. : 611-75-6

MCE 国际站：Bromhexine hydrochloride

产品活性：Bromhexine hydrochloride 是一种有效的，特异性的 TMPRSS2 蛋白酶抑制剂，IC₅₀ 为 0.75 μM。Bromhexine hydrochloride 可以预防和控制 SARS-CoV-2 感染。Bromhexine hydrochloride 是一种自噬激活剂。Bromhexine hydrochloride 是一种粘液溶解性咳嗽抑制剂，具有用于多种呼吸疾病研究的潜力。

研究领域：Anti-infection  |  Autophagy

作用靶点：SARS-CoV  |  Autophagy  |  HIV

In Vitro: Bromhexine hydrochloride (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2.
No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.
Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.

In Vivo: Bromhexine hydrochloride (30mg/kg; ip; three times per week for 5 weeks) significantly reduces the incidence of distant metastasis to lung and liver sites from 55% in vehicle-treated animals to 20% in Wild-type C57BL/6 and TRAMP mice with PIN (prostatic intraepithelial neoplasia). The prostate glands of the mice treated with Bromhexine hydrochloride are generally substantially larger than vehicle-treated TRAMP mice.

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