MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

TMP269

CAS No. : 1314890-29-3

MCE 国际站：TMP269

产品活性：TMP269 是一种有效的，选择性的脱乙酰化酶 (HDAC) 抑制剂，能够抑制 HDAC 4/HDAC 5/HDAC 7/HDAC 9，IC₅₀ 值分别为 157 nM，97 nM，43 nM 和 23 nM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：HDAC

In Vitro: TMP269 has no impact on the mitochondrial activity and/or the viability of human CD4⁺ T cells at 10 μM, and may be used as tools to identify the endogenous substrates of the class IIa HDAC enzymes. In IEC-18 intestinal epithelial cells, TMP269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation. As with HDAC4 knockdown, TMP269 significantly enhances cytotoxicity induced by CFZ in MM cell lines, upregulating ATF4 and CHOP and inducing apoptosis. TMP269 does not hyperacetylate histone H3K9 or α-tubulin in MM cell lines, confirming that it has no inhibitory effects on class I or IIb HDACs. In a dosedependent manner, TPM269-induced cytotoxicity is associated with cleavage of caspase-8, -9, -3 and PARP, consistent with apoptosis.

In Vivo: In vivo angiogenesis assay, MDA-MB-231 cells are mixed with growth factor-reduced Matrigel and implanted subcutaneously into the flanks of nude mice. TMP269 (subcutaneous injection; 15 mg/kg; every other day; 10 days) shows an obvious antiangiogenic effect with 76% inhibition of angiogenesis in mice.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Osteogenesis Compound Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  YF479  |  KD 5170  |  HDAC-IN-48  |  Remetinostat  |  HDAC-IN-30  |  HDAC-IN-52  |  CG347B  |  Psammaplin A  |  JPS016  |  HDAC6-IN-9  |  Splitomicin  |  TNG260  |  Tacedinaline  |  G4/HDAC-IN-1  |  HPOB  |  Tubacin  |  HDAC-IN-37  |  Vorinostat-d5  |  Resminostat  |  MAO A/HDAC-IN-1  |  NCC-149  |  Tubulin/HDAC-IN-1  |  PI3K/HDAC-IN-1  |  HDAC1-IN-4  |  HDAC6/HSP90-IN-1  |  Entinostat-d₄  |  UF010  |  MOCPAC  |  Ivaltinostat  |  HDAC-IN-56

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。