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Cysteine thiol probe

CAS No. : 1947408-74-3

MCE 国际站：Cysteine thiol probe

产品活性：Cysteine Thiol Probe 是一种基于硫醇的探针，旨在标记亲电子的天然产物。Cysteine Thiol Probe 具有理想药效团探针的每个特征，并具有发色团。Cysteine Thiol Probe 能够结合基于烯酮，β-内酰胺和 β-内酯的亲电子代谢物。

研究领域：Others

作用靶点：Others

In Vitro: Cysteine Thiol Probe (Probe 1) reacts much more readily with β-lactam- and β-lactone-based electrophilic natural products, and its reactivity with epoxide-based electrophilic natural products is poor. And probe 2 reacts much faster with epoxide-containing natural products. This orthogonal reactivity allows them to be employed in extracts simultaneously. Since Cysteine Thiol Probe is brominated and probe 2 is chlorinated, the isotopic patterns of labeled natural products point toward their structural origin. Competition experiments using Cysteine Thiol Probe and 2 indicated that brominated Cysteine Thiol Probe reacted exclusively with the β-lactam in penicillin G and the β-lactone in salinosporamide A while chlorinated probe 2 alone reacted with the epoxide in salinamide A.

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