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CAS No. : 496807-11-5
MCE 国际站:Beraprost sodium
产品活性:Beraprost sodium 是一种前列环素类似物,是一种稳定且具有口服活性的 PGI2 前体。Beraprost sodium 是有效的血管扩张剂 (vasodilator),通过扩张肾血管,改善微循环而具有研究肺动脉高压的潜力。
研究领域:GPCR/G Protein
作用靶点:Prostaglandin Receptor
In Vitro: Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity. Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment let VE-cadherin at regions of cell–cell contact becomes more abundant and the morphology of endothelial cells tends to be normal compared with those cultured under hypoxia conditions.
In Vivo: Beraprost sodium (oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days) can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis.
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