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CAS No. : 1202580-59-3
MCE 国际站:GPP78
产品活性:GPP78 (CAY10618) 是一种有效的烟酰胺磷酸核糖转移酶 (Nampt) 抑制剂,对 NAD 消耗的 IC50 为 3 nM。GPP78 通过诱导自噬对神经母细胞瘤细胞 SH-SY5Y 具有毒性,IC50 为 3.8 nM。GPP78 具有抗癌和抗炎作用。
研究领域:Metabolic Enzyme/Protease | Autophagy
作用靶点:NAMPT | Autophagy
In Vitro: GPP78 (Compound 8; 10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes.
GPP78 (Compound 8) inhibits the growth of most cell lines tested, with nanomolar potency (GI50) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic.
In Vivo: GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice.
相关产品:OT-82 | SBI-797812 | CB 300919 | GNE-617 | NAT | Nampt degrader-2 | GNE-618 | Nampt-IN-10 trihydrochloride | Nampt-IN-5 | NAMPT degrader-1 | CB30865 | NAMPT inhibitor-linker 2 | Nampt-IN-1 | Nampt activator-1 | Teglarinad chloride | LB-60-OF61 hydrochloride | STF-118804 | Nampt-IN-9 | CHS-828 | Nampt activator-3 | LB-60-OF61 | Nampt-IN-3 | Nampt-IN-8 | Nampt-IN-10 TFA | Nampt-IN-7 | (E)-Daporinad | Nampt activator-2 | NAMPT/IDO1-IN-1
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