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CAS No. : 826-39-1
MCE 国际站:Mecamylamine hydrochloride
产品活性:Mecamylamine hydrochloride 是一种具有口服活性,非选择性,非竞争性的 nAChR 拮抗剂。Mecamylamine hydrochloride 也是一种神经节阻滞剂,可穿过血脑屏障。Mecamylamine hydrochloride 可用于神经疾病,高血压,抗抑郁的研究。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling | GPCR/G Protein | Immunology/Inflammation
作用靶点:nAChR | Histamine Receptor
In Vitro: Mecamylamine hydrochloride (0.5-9 μM, bath administered) increases the firing frequency of identified 5-HT DRN (dorsal raphe nucleus) neurons.
?Mecamylamine hydrochloride (0.5-9 μM, bath administered) increases the glutamatergic and decreases the GABAergic input of 5-HT DRN neurons.
?Mecamylamine hydrochloride (1 mM, 5 min) blocks the histamine receptor and the histamine-induced contractions in helically cut strips of rabbit aorta.
?Mecamylamine hydrochloride (1-100 nM, 30 min) dose-dependently attenuates endothelial tube formation in HDMVECs.
In Vivo: Mecamylamine hydrochloride (subcutaneous pumps, 50 mg/kg/day, 2 days) inhibits Choroidal neovascularization (CNV) in CNV mice model.
?Mecamylamine hydrochloride (intraperitoneal injection, 0.5-1 mg/kg) has antidepressant-like effects in both the TST (tail suspension test) and FST (forced swim test) in C57BL/6J mice, which are dependent on both β2 and α7 subunits.
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