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CAS No. : 574759-62-9
MCE 国际站:VAF347
产品活性:VAF347 是一种细胞可渗透且高度亲和力的芳烃受体 (AhR) 激动剂,可诱导 AhR 信号传导。VAF347 抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+ 单核细胞的发育。VAF347 具有抗炎作用。
研究领域:Immunology/Inflammation
作用靶点:Aryl Hydrocarbon Receptor
In Vitro: VAF347 (0.01-20 μM; 48-72 hours; HL-60 cells) treatment enhances retinoic acid-induced cell cycle arrest.
VAF347 (20 μM; 48 hours; HL-60 cells) treatment augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of partners in the signalsome appear to be enhanced: Fgr interaction with c-Cbl, CD38, and with pS259c-Raf and AhR interaction with c-Cbl and Lyn.
VAF347 inhibits IL-4+ GM-CSF induced IL-6 production in MM1 cells with an IC50 of ~5 nM.
In Vivo: In wild-type mice, VAF347 treatment leads to a strong reduction of total serum IgE levels compared with vehicle-treated animals. IL-5 levels in the bronchoalveolar fluid are inhibited to a comparable degree. AhR-deficient mice are resistant to the VAF347's ability to block allergic lung inflammation in vivo.
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