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CAS No. : 105650-23-5
MCE 国际站:PhIP
产品活性:PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) 是在熟肉中形成的杂环芳香胺 (HAA),是一种可能的致癌物。具有 DNA 破坏性和诱变性。PhIP 还具有雌激素活性,可能有助于其组织特异性致癌性。
研究领域:Others
作用靶点:Others
In Vitro: PhIP causes widespread and largely over-lapping effects on miRNA expression. PhIP induces widespread effects via activation of oestrogen receptor alpha (ERα). Deregulation of miRNA by PhIP could potentially be an important non-DNA-damaging carcinogenic mechanism in breast cancer.
In Vivo: In hCYP1A-mice, PhIP induces inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe. PhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents.
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