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Methyclothiazide

CAS No. : 135-07-9

MCE 国际站：Methyclothiazide

产品活性：Methyclothiazide 是一种口服降压试剂 (antihypertensive) 和利尿剂 (diuretic agent)。Methyclothiazide 减少内源性血管收缩刺激 (如，去甲肾上腺素: HY-13715) 引起的血管反应。Methyclothiazide 拮抗体外的电压依赖性钙通道的 (VDCC) 活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Carbonic Anhydrase

In Vitro: Methyclothiazide (0-100 μM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from SHR, and the maximal vasoconstrictive effect of Norepinephrine (HY-13715) and arginine vasopressin (AVP) is decreased by 59% and 32.3 %, respectively.
Methyclothiazide (0-100 μM) induces inhibitory effect on the contractile response to Norepinephrine (HY-13715) is abolished by N-nitro-L-arginine (NOLA) but not indomethacin.
Methyclothiazide (100 μM) affects the vascular responses to extracellular Ca²⁺ under high-K⁺ depolarizing conditions. It can reduce Ca²⁺ contracture in a high-K⁺, Ca²⁺-free solution. The maximal contracture is reduced by 90.4%.

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