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Ropivacaine

CAS No. : 84057-95-4

MCE 国际站：Ropivacaine

产品活性：Ropivacaine 是一种有效的钠通道 (sodium channel) 阻断剂。Ropivacaine 通过可逆地抑制钠离子内流 (sodium ion influx) 从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K_2P (双孔钾通道) TREK-1 的抑制剂，在 COS-7 细胞膜上的 IC₅₀ 值为 402.7 μM。Ropivacaine 用于神经性疼痛的缓解的相关研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel  |  Potassium Channel

In Vivo: Epidural administration of Ropivacaine effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.
Ropivacaine inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).
Ropivacaine prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.
Ropivacaine inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs.

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