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2,4-Diamino-6-hydroxypyrimidine

CAS No. : 56-06-4

MCE 国际站：2,4-Diamino-6-hydroxypyrimidine

产品活性：2,4-Diamino-6-hydroxypyrimidine 是一种特异的 GTP cyclohydrolase I (蛋白从头合成中的限速酶) 的抑制剂。2,4-Diamino-6-hydroxypyrimidine 可阻断 Tetrahydrobiopterin (BH4) 的合成并抑制 NO 的产生。

研究领域：Immunology/Inflammation

作用靶点：NO Synthase

In Vitro: 2,4-Diamino-6-hydroxypyrimidine (DAHP) exhibits a dose-dependent reduction in NO production in both chicken peritoneal macrophages (PECs) and the avian MC29 virus-transformed macrophage cell line, HD11.
2,4-Diamino-6-hydroxypyrimidine (DAHP; 5 mM; 24 hours) treatment significantly reduces both BH4 and VCAM-1 levels during the time course in HUVEC cells. 2,4-Diamino-6-hydroxypyrimidine reduces VCAM-1 and GTPCH protein synthesis at least partially via suppressing the NF-κB level in the nucleus of HUVEC.
2,4-Diamino-6-hydroxypyrimidine (DAHP) is first identified as an inhibitor of the biopterin-dependent growth of the protozoan Crithidia fasciculate.

In Vivo: When 2,4-Diamino-6-hydroxypyrimidine (DAHP) is administered for 4 days at the dose of 3 g/kg/day in mice, serotonin decreased in the duodenum and colon to approximately 46% and 40% of the control levels, respectively. 2,4-Diamino-6-hydroxypyrimidine causes a rapid decrease (T_1/2 of less than 12 hr) in the BH4 levels in all tissues examined, except in the brain. The BH4 level returned to within the normal range less than 24 hr after cessation of the administration of 2,4-Diamino-6-hydroxypyrimidine.

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