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CAS No. : 237430-03-4
MCE 国际站:Alsterpaullone
产品活性:Alsterpaullone (9-Nitropaullone) 是一种高效的 CDK 抑制剂,作用于 CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E 和 CDK5/p35 的 IC50 值分别为 35 nM、15 nM、200 nM 和 40 nM。Alsterpaullone 是 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂,且作用的 IC50 值都为 4 nM。Alsterpaullone 具有抗肿瘤活性,有用于神经退行性和增生性疾病研究的潜力。Alsterpaullon 诱导白血病细胞凋亡 (apoptosis)。
研究领域:Cell Cycle/DNA Damage | Stem Cell/Wnt | PI3K/Akt/mTOR | Apoptosis
作用靶点:CDK | GSK-3 | Apoptosis
In Vitro: Alsterpaullone (0.3, 1, 3 μM; 8 hours) induces apoptosis in leukemia cell line.
Alsterpaullone (5, 10, 15, 20, 25, 30 μM; 48 and 72 hours) inhibits the growth of HeLa cells in dose-and time-dependent manner. Treatment with Alsterpaullone causes a time-dependent inhibition of cell growth too.
Alsterpaullone (20 μM) induces cell death depending on caspase activity.
In Vivo: Alsterpaullone (30 mg/kg, s.c., daily for 2 weeks) reduces tumor growth and increases survival in medulloblastoma xenografts.
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