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Sonolisib

CAS No. : 502632-66-8

MCE 国际站：Sonolisib

产品活性：Sonolisib (PX-866)，一种改良的 Wortmannin 类似物，是一种可口服的，不可逆的，泛亚型的 PI3K 抑制剂 (IC₅₀=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ))。PX-866 具有出抗肿瘤活性。

研究领域：PI3K/Akt/mTOR

作用靶点：PI3K

In Vitro: Sonolisib (PX-866) inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations.

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