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CAS No. : 1314081-53-2
MCE 国际站:Vicagrel
产品活性:Vicagrel 是一种有效且安全的抗血小板剂,具有口服活性,通过不可逆地抑制 P2Y12 受体起作用。Viagrel 可用于冠状动脉疾病、外周血管疾病和脑血管疾病中血栓的研究。
研究领域:GPCR/G Protein
作用靶点:P2Y Receptor
In Vitro: Vicagrel (compound 9a) (20 μM, 30 min) activates production of the active metabolite from in vitro rat liver microsomal.
In Vivo: Vicagrel (compound 9a) (oral, 3 mg/kg) has inhibitory effect on ADP-induced platelet aggregation in rats.
Vicagrel (oral, 1.14 mg/mL, 0-24 h) has giood preliminary pharmacokinetic with high bioavailability and low clinically effective dose.
Vicagrel (oral, 5 g/kg, single, for 14 days) has low dose-related toxicity in mouse.
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