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E3330

CAS No. : 136164-66-4

MCE 国际站：E3330

产品活性：E3330 (APX-3330) 是一种直接，口服有效的，选择性的 Ape-1 (无嘌呤/嘧啶内切酶 1)/Ref-1 (氧化还原因子 -1) 氧化还原的抑制剂。E3330 能抑制胰腺癌组织中 NF-κB、AP-1、HIF-1α 的活性。E3330 具有抗癌活性。

研究领域：Cell Cycle/DNA Damage  |  NF-κB  |  Immunology/Inflammation  |  Metabolic Enzyme/Protease  |  Protein Tyrosine Kinase/RTK

作用靶点：DNA/RNA Synthesis  |  NF-κB  |  AP-1  |  HIF/HIF Prolyl-Hydroxylase  |  VEGFR  |  Reactive Oxygen Species

In Vitro: E3330 (0-50 μM, 48 h) inhibits the growth of HUVECs, PCECs and EPCs.
E3330 (0-5 μM) reduces secreted and intracellular VEGF (vascular endothelial growth factor) expression by pancreatic cancer cells, while concomitantly downregulating the cognate receptor Flk-1/KDR on PCECs.
E3330 (0-1 μM) inhibits the differentiation of bone marrow mesenchymal stem cells (BM-MSCs) into CD31⁺ cells of endothelial lineage.
E3330 (0-50 μM, 72 h) decreases cell viability in H1975 cells about 45% at 50 μM.
E3330 (0-30 μM) inhibits the growth and migration of pancreatic cancer cells.
E3330 (0-30 μM) significantly enhances intracellular ROS level and inhibits CD44 expression in PANC1 cells.

In Vivo: E3330 (25 mg/kg, Orally, 5 daily, five days each week for three weeks) is neuroprotective against cisplatin-induced alterations in capsaicin-induced vasodilation.
E3330 (0-100 mg/kg, Orally, once) attenuates the liver injury when given at 1 h, 6 h or 12 h after galactosamine challenge.

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