MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1422500-60-4
MCE 国际站:Ziresovir
产品活性:Ziresovir (AK0529; RO-0529) 是一种口服有效的,选择性呼吸道合胞病毒 (RSV) 融合 (F) 蛋白 (RSV F) 抑制剂。 Ziresovir 显示抗 RSV 活性 (EC50=3 nM), 并具有药代动力学表现。
研究领域:Anti-infection
作用靶点:RSV
In Vitro: Ziresovir shows different efficacy in Wild Type (WT) and Mutant Strains RSV with EC50/EC90 values (μM) of 0.003/0.005 (WT), 2.1/10.0 (D486N), and >10/>10 (D489A), respectively.
RO-0529 (100 nM; 4 d) inhibits RSV F protein-induced cell–cell fusion process, and suppresses the syncytia formation induced by the RSV F protein.
In Vivo: Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) results reduction of RSV titer in mouse lung.
Ziresovir (10 mg/kg; p.o.; single dose) exhibits good oral exposure and bioavailability with F(%) of 32% in male Wistar-Han rats.
Ziresovir (150 mg/kg; p.o.; single dose) demonstrates a high tissue distribution to lung than plasma in CD-1 Mice.
Pharmacokinetics of Ziresovir in male Wistar-Han rats
Dose (mg/kg) | AUC0-24h(p.o.) (ng·h/mL) | CL (mL/min/kg) | T1/2(i.v.) (h) | Vss (L/kg) | F (%) |
2 mg/kg (iv) or 10 mg/kg (po) | 906 | 58 | 1.2 | 3.9 | 32 |
Pharmacokinetics of Ziresovir in CD-1 MiceDose (mg/kg) | AUC0-24h(p.o.) (μg·h/L) | tissue/lasma AUC0-24h ratio (μg·h/L) | T1/2 (h) | Tmax (h) | Cmax (μg/L) |
plasma | 8,380 | 1 | 1.02 | 0.25 | 5090 |
lung | 72,400 | 8.6 | 3.31 | 1 | 22700 |
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Clinical Compound Library | Antiviral Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Children’s Drug Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | BMS-433771 | Roflumilast | RSV604 (R enantiomer) | Ribavirin | VV116 | Gontivimab | GS-443902 trisodium | TMC353121 | Presatovir | 3,4-Di-O-caffeoyl quinic acid methyl ester | JNJ 2408068 | Sophoranol | (S)-Enzaplatovir | hRSV-IN-1 | RSV-IN-6 | RSV-IN-4 | RSV-IN-1 | AVG-233 | RD3-0028 | RSV-IN-7 | Felvizumab | Nirsevimab | Roflumilast-d3 | Rostafuroxin | RSV/IAV-IN-1 | RSV-IN-2 | Motavizumab
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。