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CAS No. : 154-42-7
MCE 国际站:6-Thioguanine
产品活性:6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) 是一种抗白血病和免疫抑制剂,为 SARS 和 MERS 病毒木瓜样蛋白酶 (PLpros) 的抑制剂,同时可有效抑制 USP2 的活性,IC50 值分别为 25 μM 和 40 μM。
研究领域:Anti-infection | Cell Cycle/DNA Damage | Epigenetics | Autophagy | Apoptosis | Metabolic Enzyme/Protease
作用靶点:SARS-CoV | Deubiquitinase | DNA Methyltransferase | Autophagy | Apoptosis | Endogenous Metabolite
In Vitro: 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. 6-Thioguanine (Thioguanine) affects the methylation of cytosine residues by purified DNA methyltransferases including human DNMT1 and bacterial HpaII methylase. 6-Thioguanine (Thioguanine) (1 or 3 μM) decreases global cytosine methylation in Jurkat T cells and cytosine methylation in human cells at 3 μM. 6-Thioguanine (Thioguanine) (18.75, 37.50, or 75.00 μM) adversely affects cell viability, but with no effect on LDH or ALT activity.
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