MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

KN-93 hydrochloride

CAS No. : 1956426-56-4

MCE 国际站：KN-93 hydrochloride

产品活性：KN-93 hydrochloride是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，K_i 为370 nM。

研究领域：Neuronal Signaling  |  Autophagy

作用靶点：CaMK  |  Autophagy

In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H⁺, K⁺-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca²⁺-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Autocamtide-3  |  Trifluoperazine dihydrochloride  |  Calmodulin-Dependent Protein Kinase II(290-309) acetate  |  Cabamiquine  |  TX-1123  |  Autocamtide-2-related inhibitory peptide, myristoylated TFA  |  CS587  |  CaMKII-IN-1  |  TIM-063  |  KN-93 phosphate  |  KN-62  |  A-484954  |  Ph-HTBA  |  Autocamtide 2, amide  |  K-252a  |  Sordarin sodium  |  Calmidazolium chloride  |  MLCK inhibitor peptide 18  |  Syntide 2 TFA  |  Autocamtide-2-related inhibitory peptide  |  Trifluoperazine-d₃ dihydrochloride  |  Rimacalib  |  Calmodulin Dependent Protein Kinase Substrate Analog  |  PROTAC eEF2K degrader-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。