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CAS No. : 217500-96-4
MCE 国际站:Tulathromycin A
产品活性:Tulathromycin A (Tulathromycin) 是一种大环内酯类抗生素 (antibiotic),通过靶向细菌核糖体抑制蛋白质合成 (IC50=0.26 µM)。Tulathromycin A 用于研究牛和猪的呼吸道疾病。具有免疫调节作用。
研究领域:Anti-infection
作用靶点:Antibiotic | Bacterial
In Vitro: Tulathromycin A (Tulathromycin) represents the first member of a novel subclass of macrolides, known as triamilides.
Tulathromycin A (0.02 to 2.0 mg/mL) induces time- and concentration-dependent apoptosis in neutrophils, which enhances their subsequent clearance by macrophages.
In Vivo: In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs.
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