MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 99-66-1
MCE 国际站:Valproic acid
产品活性:Valproic acid (VPA) 是一种具有口服活性的 HDAC 抑制剂,IC50 值为 0.5-2 mM,抑制 HDAC1 的活性,(IC50,400 μM),同时可诱导 HDAC2 的降解。Valproic acid 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍、代谢疾病、HIV 感染和偏头痛等的研究。
研究领域:Cell Cycle/DNA Damage | Epigenetics | Autophagy | Anti-infection | Stem Cell/Wnt | Neuronal Signaling | Apoptosis | Metabolic Enzyme/Protease
作用靶点:HDAC | Autophagy | Mitophagy | HIV | Notch | Apoptosis | Endogenous Metabolite
In Vitro: Valproic acid (VPA) (0-15 mM; 24 and 72 h) inhibits Hela cell growth in a dose- and time- dependent manner.
Valproic acid (10 mM; 24 h) significantly attenuates the activities of total, cytosol and nuclear HDACs.
Valproic acid (0-15 mM; 24 h) induces a G1 phase arrest at 1–3 mM and a G2/M phase arrest at 10 mM, and increases the percentage of sub-G1 cells in HeLa cells. Valproic acid also induces necrosis, apoptosis and lactate dehydrogenase (LDH) release.
Valproic acid (0-20 mM; 24 h) activates Tcf/Lef-dependent transcription and synergizes with lithium.
Valproic acid (0-5 mM; 0-18 h) increases β-catenin levels in Neuro2A cells.
Valproic acid (0-2 mM; 0-24 h) stimulates phosphorylation of AMPK and ACC in hepatocytes.
Valproic acid (0-10 mM; 2 days) induces Notch1 signaling and morphologic differentiation, suppresses production of NE tumor markers in SCLC cells.
In Vivo: Valproic acid (VPA) (500 mg/kg; i.p.; daily for 12 days) inhibits tumor angiogenesis in mice transplanted with Kasumi-1 cells.
Valproic acid (350 mg/kg; i.p.; once) enhances social behavior in rats.
Valproic acid (0.26% (w/v); p.o. via drinking water; 14 days) decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice without hepatotoxicity.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | D-Valine-d8 | SY-5609 | D-α-Hydroxyglutaric acid disodium | BRD4 Inhibitor-18 | Nicotinamide N-oxide | 8α-Tigloyloxyhirsutinolide 13-O-acetate | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | AAPK-25 | Peldesine dihydrochloride | Dutasteride-13C6 | Adrenaline sulfate | Oleic acid-13C | Dextranase | H2S Donor 5a | Anticancer agent 120 | Abacavir sulfate | Methylmalonic acid | Meloxicam-d3-1 | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | YF479 | Thailanstatin D | SB-218078 | Toyocamycin | HIV-IN-6 | Sorafenib-d4 | Sphingomyelin
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。