MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2301866-59-9
MCE 国际站:DO-264
产品活性:DO-264 是一个具有体内活性的、自水解酶结构域 12 (ABHD12) 的抑制剂,其 IC50 值为 11 nM。
研究领域:Metabolic Enzyme/Protease
作用靶点:MAGL
In Vitro: DO-264 displays an IC50 value of 11 nM (9.6 nM-13 nM). DO-264 blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates (DO-264 IC50 values of ~30 and 90 nM against mouse and human ABHD12, respectively) and the ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain (IC50=2.8 nM, 2.4 nM-3.3 nM) and human THP-1 cells (IC50= 8.6 nM, 6.3 nM-12 nM).
In Vivo: Mice treated with DO-264 display dose-dependent increases in brain lyso-PS and 20:4 PS content that are qualitatively similar to the changes observed in ABHD12–/– mice. DO-264-treated mice, however, show minimal impairment in auditory function following four weeks of drug exposure. Both ABHD12–/– and DO-264-treated mice display exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death.
相关产品:Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Chemical Probe Library | Anti-Cancer Metabolism Compound Library | Lipid Metabolism Compound Library | Highly Selective Inhibitors Library | MAGL-IN-4 | PF-06795071 | KT185 | JZP-MA-11 | KT109 | JZL195 | DH-376 | JZP-430 | JW 642 | MJN110 | WWL123 analogue-1 | Euphol | MAGLi 432 | AA38-3 | KT203 | FAAH-IN-5 | SAR629 | LEI-106 | MAGL-IN-6 | Monoacylglycerol lipase inhibitor 1 | 7-Hydroxycoumarinyl arachidonate | FAAH/MAGL-IN-2 | ML-226 | ML-211 | Arachidonoyl Serinol | KML29 | MAGL-IN-1 | FAAH/MAGL-IN-3 | MAGL-IN-5
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。