MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1887014-12-1
MCE 国际站:Olutasidenib
产品活性:Olutasidenib (FT-2102) 是一种,具有口服活性的、能透过血脑屏障的、突变型异柠檬酸脱氢酶 (IDH)1 的选择性有效抑制剂,对IDH1- R132H 和 IDH1- R132C的 IC50 值分别为 21.2 nM 和 114 nM。可用于研究急性髓性白血病或骨髓增生异常综合征。
研究领域:Metabolic Enzyme/Protease
作用靶点:Isocitrate Dehydrogenase (IDH)
In Vitro: Olutasidenib (FT-2102) potently inhibits 2-HG production by multiple IDH1-R132 mutants (R132H, R132C, R132G, R132L), suggesting Olutasidenib (FT-2102) could be efficacious against most IDH1-R132 mutant-expressing tumors. Olutasidenib (FT-2102) is highly selective for IDH1 isoforms, showing no appreciable inhibition against wild-type IDH1 (> 20 µM) and IDH2 mutants (R172K and R140Q: both > 20 µM).
In Vivo: Olutasidenib (FT-2102, three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals) exhibits potent anti-tumor activity in HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice.
相关产品:Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Mitochondria-Targeted Compound Library | Glucose Metabolism Compound Library | Rare Diseases Drug Library | TCA Cycle Compound Library | Highly Selective Inhibitors Library | Vorasidenib | Mutant IDH1-IN-4 | IDH-305 | IDH889 | (S,S)-GSK321 | IDH1 Inhibitor 1 | DS-1001b | IDH1 Inhibitor 7-d2 | IDH2R140Q-IN-1 | Mutant IDH1-IN-1 | IDH1 Inhibitor 3 | (R,S)-Ivosidenib | IDH1 Inhibitor 5 | AGI-5198 | AGI-12026 | AGI-6780 | IDH1 Inhibitor 2 | Enasidenib | GSK321 | IDH-C227 | Mutant IDH1 inhibitor | Mutant IDH1-IN-2 | mIDH1-IN-1
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。