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Ceftizoxime

CAS No. : 68401-81-0

MCE 国际站：Ceftizoxime

产品活性：Ceftizoxime是一种细菌抑制剂，其通过干扰细菌细胞壁合成和抑制肽聚糖的交联起作用。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Ceftizoxime is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and Serratia marcescens, than cephalosporins and cephamycins such as cefotiam, cefamandole, cefuroxime, cefotaxime, and cefmetazole. Ceftizoxime shows a broad spectrum of antibacterial activity against aerobic gram-positive and gram-negative bacteria.

In Vivo: The therapeutic effect of Ceftizoxime in mice infected with a small inoculum size is almost the same as that of cefotaxime. Ceftizoxime is stable in biological fluids such as serum, urine, and tissue homogenates, but cefotaxime is unstable in rat tissue homogenates. Binding of ceftizoxime to serum protein in all species is the lowest of all the antibiotics: 31% for humans, 17% for dogs, and 32% for rats.

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