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Cilengitide TFA

CAS No. : 199807-35-7

MCE 国际站：Cilengitide TFA

产品活性：Cilengitide 是有效的，选择性的 α_vβ₃ 和 α_vβ₅ 受体整合素抑制剂，IC₅₀ 分别为 4 nM 和 79 nM。

研究领域：Cytoskeleton  |  Autophagy

作用靶点：Integrin  |  Autophagy

In Vitro: Cilengitide (EMD 121974) is the α_vβ₃ and α_vβ₅ integrin receptor antagonist. In cell adhesion studies assessing the human melanoma M21 or UCLA-P3 human lung carcinoma cell lines, Cilengitide inhibits integrin-mediated binding to vitronectin with IC₅₀s of 0.4 and 0.4 μM. In vitro treatment of Cilengitide, at a concentration greater than 1 µM, shows concentration- and time-dependent cytotoxic effects .

In Vivo: In nude mice bearing M21-L melanoma tumors, Cilengitide dose i.p. at 10, 50, and 250 μg three times per week demonstrate inhibition of tumor growth with a reduction in both tumor volume (55%, 75%, and 89%, respectively) and tumor weight (23%, 38%, and 61%, respectively), when compared to controls. In the rat model studied, the systemic pharmacokinetics of i.p. Cilengitide are not affected by ILP with Cilengitide alone or ILP with Cilengitide plus Melphalan, TNF or both. Systemic Cilengitide levels reach around 20 µg/mL (approximately 35 µM) within 10 min of i.p. administration and continued to rise to approximately 40 µg/mL (approximately 70 µM) in the first hour. Thereafter Cilengitide levels in serum drop with an elimination half-life of 2.1 hr.

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